Klomen 50 mg Kocak Farma (Copy)

Descrription of Klomen

Clomid (Clomiphene Citrate) belongs to a category and class of drugs known as selective Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as Aromasin (Exemestane) and Arimidex (Anastrozole). AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. The misunderstanding that SERMs, such as Nolvadex and Clomid, serve to lower estrogen levels must first be addressed before delving into any further details.

This is a persistent rumor among the anabolic steroid using community that has begun to erode as of late, but the rumor still persists. SERMs serve to block the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. Conversely, SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Nolvadex’s case). SERMs do not lower circulating levels of Estrogen in blood plasma. Aromatase inhibitors serve to do this by eliminating the production of Estrogen through binding to and disabling the aromatase enzyme, which is the enzyme responsible for the conversion (or aromatization) of androgens into Estrogen.

Clomid was developed and approved for use in the early 1970s for the treatment of female infertility (and later on subsequently expanded to treating male infertility as well). Not too long after its release in the United States, its popularity and use spread internationally where, like Nolvadex, its popularity and rate of use is so massive that it is widely and freely available in the majority of countries and regions across the world under an almost infinite number of brand names as well as generic products. Its popularity and cheap cost make it a very easily attainable compound for both medical use as well as off-label use for the anabolic steroid using community.

Clomid, although it is classified as an anti-Estrogen, is actually utilized for the treatment of female infertility resulting from ovulation failure (anovulatory infertility). Although Clomid is a very close relative to Nolvadex with both belonging to the SERM category of drugs, Clomid in reality operates at a much poorer efficiency compared to Nolvadex in regards to its Estrogen antagonistic activity in breast tissue. This is to say that it is a weaker Estrogen blocker in breast tissue, where Nolvadex is much better suited for this task. Instead, Clomid’s prime application in medicine is that of a non-steroidal ovulatory stimulant for women. Because Clomid is a SERM, like Nolvadex, it exhibits mixed Estrogen agonist and antagonist effects in various tissues of the body. Like Nolvadex, Clomid acts as an Estrogen antagonist in the hypothalamus, pituitary gland, ovaries, endometrium, vagina, and cervix. This is to say that in these tissues and areas of the body, Clomid serves to mitigate (inhibit or block) the action of Estrogen.